RATIONAL DRUG DESIGN OF POTENT V600E-BRAF KINASE INHIBITORS THROUGH MOLECULAR DOCKING SIMULATION
نویسندگان
چکیده
منابع مشابه
Insight into molecular dynamics simulation of BRAF(V600E) and potent novel inhibitors for malignant melanoma
BRAF inhibitors have changed the standard therapeutic protocol for advanced or metastatic melanoma which harbored notorious BRAF(V600E) single mutation. However, drug resistance to BRAF inhibitors happens just like other cancer treatment. In this study, we constructed the ideal BRAF(V600E)-modeled structure through homology modeling and introduced the method of structure-based docking or virtua...
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ژورنال
عنوان ژورنال: The Journal of Engineering and Exact Sciences
سال: 2019
ISSN: 2527-1075
DOI: 10.18540/jcecvl5iss5pp0469-0481